Physiology & pathophysiology of Peritoneal Dialysis Physiology and pathophysiology of peritoneal dialysis. Mechanisms of solute and fluid exchange across the blood peritoneal barrier (peritoneal membrane). Vasoactive properties of peritoneal dialysis solutions.

Physiology & Pathophysiology of Hemorrhagic Shock & Resuscitation. Physiology and pathophysiology of hypovolemic shock. Development of new novel resuscitation methods.

Direct Intracellular energy delivery The recognition of the pathophysiologic events during traumatic shock and their relationship to local and remote tissue injuries, which culminate into multiple organ failure, has gradually evolved during the last few decades. Early studies have demonstrated the relationship between intracellular volume and subsequent alterations in cell membrane functions during hemorrhagic shock. These membrane alterations which include a decrease in transmembrane potential and an associated cellular swelling, are thought to be due to a decrease in ATP-dependent sodium-potassium exchange and an increase in intracellular sodium, water and calcium. Our research focuses on the development of new techniques to replenish depleted cellular energy stores. we utilized new specially formulated, highly fusogenic, unilamellar lipid vesicles that contain ATP (VitaSol™). This novel technique allows for delivery of high energy phosphate directly into the cytosol of the endothelial cells of the intestinal microvasculature.